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Diet Guide

High-Protein Diet Guide for GLP-1 Medications

Daily protein targets by body weight, plus a high-protein food chart, to help preserve muscle while losing fat on semaglutide or tirzepatide.

Educational use only

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Licensed Clinicians
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Compounded in the USA
10,000+ Members Trust iSTRYVE

This guide is for general education, not medical or nutrition advice. Protein needs vary by age, activity level, and health history — talk with your provider or a registered dietitian before changing your diet significantly.

Why protein matters on a GLP-1 medication

When you lose weight quickly on a reduced appetite, your body pulls from both fat and muscle stores for energy — unless you give it enough protein to protect the muscle. Getting enough protein, combined with staying active, is one of the most effective ways to keep the weight you lose as fat loss rather than muscle loss.

Daily protein targets by body weight

Body weightLower target (~0.6g/lb)Higher target (~0.8g/lb)
120–150 lb72–90 g/day96–120 g/day
150–180 lb90–108 g/day120–144 g/day
180–210 lb108–126 g/day144–168 g/day
210–240 lb126–144 g/day168–192 g/day
240+ lb144+ g/day192+ g/day

General reference ranges, not a prescription. More active patients, or those strength training, often benefit from the higher end of the range.

High-protein food chart

FoodProtein
Chicken breast (4 oz)~35 g
Greek yogurt (1 cup, plain)~20–23 g
Eggs (2 large)~12 g
Salmon (4 oz)~29 g
Cottage cheese (1 cup)~25 g
Tofu, firm (4 oz)~10 g
Whey or plant protein shake (1 scoop)~20–25 g
Lentils, cooked (1 cup)~18 g

Tips for hitting your target with a small appetite

Frequently asked questions

Rapid weight loss from reduced calorie intake can include muscle loss, not just fat loss, if protein intake is too low. Prioritizing protein at each meal helps your body preserve lean muscle while losing fat.

The ranges above use roughly 0.6–0.8 g of protein per pound of body weight per day, a common range used for weight loss with muscle preservation. Your individual needs can vary based on activity level, age, and health history — ask your provider or a dietitian for a personalized number.

This is common. Prioritize protein first at each meal before other foods, consider a protein shake between meals, and choose protein-dense options (Greek yogurt, eggs, cottage cheese) over bulkier, lower-protein foods.

Yes. A shake is often the easiest way to hit your target on a reduced appetite — just check it doesn't also add a lot of added sugar.

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